Sulfamethoxazole is an antibacterial or antimicrobial sulphonamide.
Members of this group act as an analogue of PABA (para-amino benzoic acid) and inhibit an enzyme that is involved in folate synthesis, thus starving the bacteria of the B-group vitamin folate. Trimethoprim
inhibits a subsequent step in the reaction so it may act synergistically and sulfamethoxazole is often used in combination with trimethoprim (as co-trimoxazole).
It may be used against susceptible forms of Streptococcus
, Staphylococcus aureus
(including MRSA), Escherichia coli
, Haemophilus influenzae
, and oral anaerobes. It is commonly used to treat urinary tract infections
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