Efavirenz is an antiretroviral medication, used to treat and prevent HIV/AIDS.
It acts as an inhibitor of HIV's reverse transcriptase enzyme, which converts viral RNA into DNA, to be incorporated into human T lymphocyte cells.
It is described as a non-nucleoside reverse transcriptase inhibitor
. NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket.
It is a substituted benzoxazine compound and its molecular structure does not resemble DNA nucleosides which interact directly with the enzyme's active site.
Its chemical name is
Efavirenz in combination with other drugs such as tenofovir/emtricitabine (Truvada) can be used as highly active antiretroviral therapy
(HAART) treatments for HIV.