Remdesivir

The Remdesivir molecule - rotatable in 3 dimensions


This substance is seen as an adenosine monophosphate analogue, and it is being tested as a treatment for COVID-19.
Carbon 1 of the ribose section is connected to a cyano (nitrile) group -C≡N as well as a heterocyclic aromatic section resembling the purine adenine, but not bonded via nitrogen.
Carbon 5 of the ribose is bonded to a single phosphate group substituted with a phenyl group as well as an amino group terminated with a bulky aliphatic chain ending with an ethybutyl group.

It is described as a pro-drug in that it is converted by intercellular enzymes into a triphosphate form of another compound GS-441524. This interferes with the action of viral RNA-dependent RNA polymerase, slowing production or causing termination of the viral RNA chain. It is said to evade proofreading by viral exoribonuclease.

The makers Gilead state that the limited preclinical data on remdesivir in MERS and SARS indicate that remdesivir may have potential activity against COVID-19. but they add that remdesivir is an experimental medicine that does not have established safety or efficacy for the treatment of any condition.

Remdesivir was originally developed to treat Ebola virus disease and Marburg virus disease but was ineffective for these viral infections.

Label/ Unlabel atoms

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DNA bases
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Nucleoside analogues
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Supporting units on this site

Structure of Nucleic Acids (DNA and RNA)
Adenosine triphosphate
HIV a section within the Cell recognition topic

Web references

Coronavirus: US authorises use of anti-viral drug Remdesivir : BBC News article
Remdesivir From Wikipedia, the free encyclopedia
Study Sheds New Light on Remdesivir's Mechanism of Action against SARS-CoV-2 Researchers from China report the structure of the antiviral drug remdesivir bound to both a molecule of RNA and to the SARS-CoV-2 viral polymerase