The Linezolid molecule - rotatable in 3 dimensions

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Linezolid is an oxazolidinone antibiotic.

Oxazolidinones are a group of synthetic chemicals, some of which were found to have antibiotic properties in the mid 1980s.

Linezolid is one such compound that came to prominence in 1996 and was approved by the FDA in 2000. It is not cheap: cost to the UK NHS is 670-890 per treatment - $1000-2000 in the US. Other oxazolidinone antibiotics are currently being developed.

It acts as a protein synthesis inhibitor, preventing the binding of transfer RNA to the bacterial ribosome.

It has been suggested as a means of controlling many bacteria (only Gram-positive) which are resistant to other antibiotics : MRSA , VRE, and penicillin-resistant Streptococcus pneumoniae. However, linezolid- resistant forms of Enterococcus faecium and Staphylococcus aureus have been found but they are not (yet) widespread.

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Web references

Linezolid August 2005 Molecule of the Month by Rafal Klajn

Linezolid From Wikipedia, the free encyclopedia

NEW MEDICINES ON THE MARKET Evaluated information for the NHS LINEZOLID