Anti-Tuberculosis Drugs

[isonicotinic acid hydrazide (INH)] is the current first line drug of choice for controlling tuberculosis.

It is used on its own for the control of latent tuberculosis and in combination with other drugs for active TB.

It works by inhibiting the formation of mycolic acid in the cell wall of Mycobacterium tuberculosis.
is a much more complicated molecule, used in conjunction with isoniazid for active TB.

It is said to bind to DNA-dependent RNA polymerase and inhibit initiation of RNA synthesis.
is also used for the control of active TB:

According to Zhang, Wade, Scorpio, Zhang and Sun , pyrazinoic acid, the active moiety of pyrazinamide, disrupts membrane energetics and inhibits membrane transport function in Mycobacterium tuberculosis.
Ethambutolright arrow
(EMB) specifically inhibits the synthesis of arabinan in cell walls of Mycobacterium tuberculosis.

The molecule exists in 2 forms: The dextrorotatory (+) isomer is 500 times as active as the (-) isomer.
was the first antibiotic remedy for tuberculosis, but is not used for that purpose nowadays.

It stops bacterial growth by damaging cell membranes and inhibiting protein synthesis.